1/7/2023 0 Comments Multidock mod 37287![]() For each cycle of Mean Field Optimisation all residue-residue sidechain interactions (up to 300,000) are pre-calculated and stored by the program. The main MultiDock algorithm uses a multiple copy representation of side chains. The memory requirements for the present version of MultiDock is 61 Mb. They were developed under SGI Irix versions 5.3 and 6.2. The series of programs comprising MultiDock are available only as executables. 1998.Īt present MultiDock is only available for SILICON GRAPHICS WORKSTATIONS or LINUX i386 For a detailed description of the program and application to protein-protein systems see Jackson et al. The results are encouraging for Protein-Inhibitor systems. ![]() MultiDock has been tested by performing refinement of large numbers of structures generated by FTDock on several protein-protein systems. MultiDock also implements a rigid-body energy minimization routine which is performed to relax the interface. MultiDock implements the self consistent Mean Field Optimisation procedure ( Koehl & Delarue 1994) but using a full conventional molecular mechanics force field with scaling of van der Waals and electrostatic interactions for unrealistically close atomic contacts. The protein is described at the atomic level by electrostatic and van der Waals interactions in which the sidechains are modelled by a multiple copy representation according to a rotamer library on a fixed peptide backbone. The program models the effects of side-chain conformational change and the rigid-body movement of the interacting proteins during refinement. The motivation for this work was to provide a rapid energy refinement protocol for the large number of putative docked complexes produced by rigid-body docking programs such as FTDock or DOCK. The program MultiDock was developed to provide a method for refining the interface between two proteins at the atomic level given an initial docked complex generated by a docking algorithm or manual docking procedure. MultiDock (v1.0) (Multiple copy side-chain refinement of Protein-Protein interfaces) The locking front door, made of steel, slides into place to secure your devices, and individual, color-changing LEDs indicate their charging and syncing statuses.Īdmittedly, we have between 5 and 10 smartphones and tablets laying around my house at any given time, so something like this would come in handy. If you’re interested in picking up a MultiDock, they start at $699 and will be available later this month.Biomolecular Modelling Group at ICRF : 3D-Dock Suite : MultiDock Available in two configurations: a single 10 bay unit and a stacked 30 bay cart complete with smooth rolling wheels, handle and a lockable laptop tray large enough to secure a 15″ MacBook Pro.”įor those wondering, MultiDock’s outer shell is made of aluminum with a clear, anodized finish. And, connecting a device that uses Apple’s new Lightning connector activates MultiDock’s Quick Charge Mode to charge these devices at the fastest possible rate, even while syncing.Ī single MultiDock is designed for easy securing to a table, desk or countertop and comes with hardware to stack up to three units in one space with charging for 10 – 30 devices from a single computer. Schools and businesses can charge any combination of mobile devices deployed. “Griffin’s exclusive ChargeSensor™ technology in MultiDock adapts on the fly to any connected iOS or Android device by providing the fastest charging rate for that device. It’s also now compatible with several smartphone and tablet models… Griffin says that it collaborated with former Apple designer Thomas Meyerhoffer to build the second-generation MultiDock, which is both lighter and more attractive than its predecessor. The redesigned charging station looks great, and can charge and sync up to 10 devices at once. Developers, teachers, and essentially anyone else with multiple USB devices will be happy to hear that Griffin has just unveiled a new version of its MultiDock.
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